CARDIAC NUCLEOTIDE LEVELS AND MITOCHONDRIAL RESPIRATION IN COPPER-DEFICIENT RATS

被引：26
|
作者：
CHAO, JCJ
MEDEIROS, DM
ALTSCHULD, RA
HOHL, CM
机构：
[1] OHIO STATE UNIV, DEPT HUMAN NUTR & FOOD MANAGEMENT, 265 CAMPBELL HALL, 1787 NEIL AVE, COLUMBUS, OH 43210 USA
[2] OHIO STATE UNIV, DEPT MED BIOCHEM, COLUMBUS, OH 43210 USA
来源：
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY | 1993年 / 104卷 / 01期
关键词：
D O I：
10.1016/0300-9629(93)90024-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
1. Male weanling Long-Evans rats were randomly assigned to either copper-adequate (6.0 mg Cu/kg feed) or copper-deficient (< 1.0 mg Cu/kg feed) diets for a 5 week period. 2. Cardiac ATP levels and energy charges did not differ between the two groups. Levels of NAD and phosphocreatine as well as the sum of pyridine nucleotides were greater in copper-deficient rats compared with copper-adequate rats using HPLC analysis. 3. Mitochondrial respiratory control ratios and oxygen consumption rates from copper-deficient rat hearts were depressed, although ADP:O ratios were similar to copper-adequate rat hearts.
引用
收藏
页码：163 / 168
页数：6
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