EFFECT OF CYCLOSPORINE-A AND ITS METABOLITES AND ANALOGS ON LIPID-PEROXIDATION IN RABBIT RENAL MICROSOMES

被引：11
|
作者：
SADEG, N
HUY, CP
MARTIN, C
WARNET, JM
CLAUDE, JR
机构：
[1] Laboratoire de Toxicologie, Faculte de Pharmacie, Paris, F-75006, 4, avenue de I'Observatoire
来源：
DRUG AND CHEMICAL TOXICOLOGY | 1993年 / 16卷 / 02期
关键词：
D O I：
10.3109/01480549309031994
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Rabbit renal microsomes were used to investigate the effect on lipid peroxidation (LPO) of cyclosporin A (CsA) and its first generation metabolites Ml, M17 and M21, and of two natural CsA analogs: cyclosporins C and D (CsC & CsD respectively), at concentrations of 1 to 10 mug/ml. No induction of lipid peroxidation was observed with these substances except CsA at a high level (10 mug/ml); but at a concentration of CsA that would be reached in vivo, no inductive effect on LPO was noted. A moderate inhibitory effect upon LPO was observed with CsC and M21, but its biological significance is questionable.
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页码：165 / 174
页数：10
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