A new clamped bit-line current-mode sense amplifier that maintains a low-impedance fixed potential on the bit lines is introduced. Using a general model for active-drive memory cells that include the two-transistor (2T) and three-transistor (3T) dynamic cells and the four-transistor/two-resistor (4T-2R) and six-transistor (6T) static cells, the new sense amplifier is shown to have a response speed that is insensitive to bit-line capacitance. Bit-line clamping also minimizes inter-bit-line voltage noise coupling.