ISOLATION AND CHARACTERIZATION OF CATABOLITE REPRESSION CONTROL MUTANTS OF PSEUDOMONAS-AERUGINOSA PAO

被引：103

作者：

WOLFF, JA

MACGREGOR, CH

EISENBERG, RC

PHIBBS, PV

机构：

[1] E CAROLINA UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL,GREENVILLE,NC 27858

[2] VIRGINIA COMMONWEALTH UNIV,DEPT MICROBIOL & IMMUNOL,RICHMOND,VA 23298

[3] WESTERN MICHIGAN UNIV,DEPT BIOL SCI,KALAMAZOO,MI 49008

来源：

JOURNAL OF BACTERIOLOGY | 1991年 / 173卷 / 15期

关键词：

D O I：

10.1128/jb.173.15.4700-4706.1991

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Independently controlled, inducible, catabolic genes in Pseudomonas aeruginosa are subject to strong catabolite repression control by intermediates of the tricarboxylic acid cycle. Mutants which exhibited a pleiotropic loss of catabolite repression control of multiple pathways were isolated. The mutations mapped in the 11-min region of the P. aeruginosa chromosome near argB and pyrE and were designated crc. Crc- mutants no longer showed repression of mannitol and glucose transport, glucose-6-phosphate dehydrogenase, glucokinase, Entner-Doudoroff dehydratase and aldolase, and amidase when grown in the presence of succinate plus an inducer. These activities were not expressed constitutively in Crc- mutants but exhibited wild-type inducible expression.

引用

页码：4700 / 4706

页数：7

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