Linking inflammation and thrombosis: Role of C-reactive protein

被引：42

作者：

Fay, William P. ^{[1
,2
]}

机构：

[1] Univ Missouri, Sch Med, Dept Internal Med & Med Pharmacol & Physiol, 5 Hosp Dr,CE344-DC095-00, Columbia, MO 65212 USA

[2] Harry S Truman Mem Vet Affairs Hosp, Res Serv, Columbia, MO 65212 USA

来源：

WORLD JOURNAL OF CARDIOLOGY | 2010年 / 2卷 / 11期

关键词：

C-reactive protein; Thrombosis; Inflamma-tion; Tissue factor; Fibrinolysis; Plasminogen activator inhibitor-1;

D O I：

10.4330/wjc.v2.i11.365

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

C-reactive protein (CRP) is a biomarker of inflammation. Increased plasma levels of CRP are associated with an increased risk of myocardial infarction. However, the correlation between plasma CRP concentration and atherosclerotic plaque burden is poor. Based on these observations, it has been hypothesized that CRP increases the risk of myocardial infarction by promoting thrombosis. This article reviews available data that link enhanced CRP expression to increased risk of thrombosis, with a focus on the effects of CRP on hemostasis, platelet function, and fibrinolysis. Overall, the available data support the hypothesis that CRP is an important mechanistic link between inflammation and thrombosis. (C) 2010 Baishideng. All rights reserved.

引用

页码：365 / 369

页数：5

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