AMINO-ACIDS AND PEPTIDES .13. SYNTHETIC STUDIES ON N-TERMINAL TRIPEPTIDE AMIDE ANALOGS OF FIBRIN ALPHA-CHAIN

被引：0

作者：

KAWASAKI, K ^{[1
]}

TSUJI, T ^{[1
]}

HIRASE, K ^{[1
]}

MIYANO, M ^{[1
]}

IMOTO, Y ^{[1
]}

IWAMOTO, M ^{[1
]}

机构：

[1] DAIICHI SEIYAKU CO LTD, RES INST, EDOGAWA KU, TOKYO 134, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1991年 / 39卷 / 03期

关键词：

CLOTTING; WATER-SOLUBLE ACTIVE ESTER; PEPTIDE SYNTHESIS; FIBRINOGEN THROMBIN CLOTTING; ANTICOAGULANT;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

N-Terminal tripeptide analogs of fibrin alpha-chain were synthesized and their inhibitory effect on fibrinogen/thrombin clotting was examined. A new water-soluble active ester, 3-pyridinium ester, was used for the synthesis. Among the synthetic peptides, H-Gly-Pro-Arg-hexamethyleneimine exhibited the highest inhibitory effect on fibrinogen-thrombin clotting.

引用

页码：584 / 589

页数：6

共 50 条

[1] AMINO-ACIDS AND PEPTIDES .18. SYNTHETIC PEPTIDES RELATED TO N-TERMINAL PORTION OF FIBRIN ALPHA-CHAIN AND THEIR INHIBITORY EFFECT ON FIBRINOGEN THROMBIN CLOTTING
KAWASAKI, K
MIYANO, M
HIRASE, K
IWAMOTO, M
CHEMICAL & PHARMACEUTICAL BULLETIN, 1993, 41 (05) : 975 - 977
[2] AMINO-ACIDS AND PEPTIDES .12. - SYNTHETIC PEPTIDES RELATED TO THE N-TERMINAL PORTION OF FIBRIN ALPHA-CHAIN AND THEIR INHIBITORY EFFECTS ON FIBRINOGEN THROMBIN CLOTTING
KAWASAKI, K
HIRASE, K
TSUJI, T
MIYANO, M
IWAMOTO, M
THROMBOSIS RESEARCH, 1989, 56 (06) : 757 - 762
[3] AMINO-ACIDS AND PEPTIDES .16. SYNTHESIS OF N-TERMINAL TETRAPEPTIDE ANALOGS OF FIBRIN ALPHA-CHAIN AND THEIR INHIBITORY EFFECTS ON FIBRINOGEN THROMBIN CLOTTING
KAWASAKI, K
HIRASE, K
MIYANO, M
TSUJI, T
IWAMOTO, M
CHEMICAL & PHARMACEUTICAL BULLETIN, 1992, 40 (12) : 3253 - 3260
[4] AMINO-ACIDS AND PEPTIDES .17. SYNTHESIS OF PEPTIDES RELATED TO N-TERMINAL PORTION OF FIBRIN ALPHA-CHAIN AND THEIR INHIBITORY EFFECT ON FIBRINOGEN THROMBIN CLOTTING
KAWASAKI, K
TSUJI, T
HIRASE, K
MIYANO, M
INOUYE, S
IWAMOTO, M
CHEMICAL & PHARMACEUTICAL BULLETIN, 1993, 41 (03) : 525 - 528
[5] N-TERMINAL AMINO-ACIDS OF ALPHA-CASEIN
MANSON, W
NATURE, 1959, 184 (4696) : 1393 - 1394
[6] SYNTHESIS OF A RETROISOMER OF N-TERMINAL TETRAPEPTIDE IN THE FIBRIN ALPHA-CHAIN AND ITS FRAGMENTS
UNKOVSKII, VI
VASILEVA, GA
EVSTIGNEEVA, RP
ZHURNAL OBSHCHEI KHIMII, 1986, 56 (07): : 1641 - 1647
[7] QUALITATIVE DETERMINATION OF N-TERMINAL AMINO-ACIDS OF PEPTIDES AND PROTEINS
BENTLEY, KW
PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 1972, 5 (NMAY): : 4 - &
[8] SYNTHESIS OF N-TERMINAL PEPTIDE OF FIBRIN ALPHA-CHAIN ANALOGS WITH GLY-PRO-ARG-PRO-LYS SEQUENCE
ILINA, AV
DAVIDOVICH, YA
ROGOZHIN, SV
ZHURNAL OBSHCHEI KHIMII, 1984, 54 (08): : 1904 - 1907
[9] N-TERMINAL AMINO-ACIDS OF THE PEPTIDES FROM MATURED CHEDDAR CHEESE
NEY, KH
MILCHWISSENSCHAFT-MILK SCIENCE INTERNATIONAL, 1985, 40 (04): : 207 - 208
[10] N-TERMINAL PROTECTION OF AMINO-ACIDS AND PEPTIDES WITH COBALT(III) COMPLEXES
MENSI, N
ISIED, SS
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1984, 188 (AUG): : 192 - INOR

← 1 2 3 4 5 →