Genome-Wide Association Studies: Progress in Identifying Genetic Biomarkers in Common, Complex Diseases

被引：0
|
作者：
Kingsmore, Stephen F. [1 ]
Lindquist, Ingrid E. [1 ]
Mudge, Joann [1 ]
Beavis, William D. [1 ]
机构：
[1] Natl Ctr Genome Resources, 2935 Rodeo Pk Dr East, Santa Fe, NM 87505 USA
来源：
BIOMARKER INSIGHTS | 2007年 / 2卷
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
Genome-wide association studies; Complex diseases; Complex traits; Genetic biomarkers; Population genetics;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Novel, comprehensive approaches for biomarker discovery and validation are urgently needed. One particular area of methodologic need is for discovery of novel genetic biomarkers in complex diseases and traits. Here, we review recent successes in the use of genome wide association (GWA) approaches to identify genetic biomarkers in common human diseases and traits. Such studies are yielding initial insights into the allelic architecture of complex traits. In general, it appears that complex diseases are associated with many common polymorphisms, implying profound genetic heterogeneity between affected individuals.
引用
收藏
页码：283 / 292
页数：10
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