THE PATHOLOGY OF THE NEURONAL CYTOSKELETON IN ALZHEIMERS-DISEASE

被引：22
|
作者：
BRION, JP
机构：
[1] Laboratory of Pathology and Electron Microscopy, Université Libre de Bruxelles, Brussels
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1160卷 / 01期
关键词：
ALZHEIMERS DISEASE; NEUROFIBRILLARY TANGLE; PHF-TAU (A68); MICROTUBULE-ASSOCIATED PROTEIN TAU; TAU PROTEIN; PHOSPHORYLATION;
D O I：
10.1016/0167-4838(92)90047-H
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The two characteristic neuropathological lesions of Alzheimer's disease are the neurofibrillary tangles and the senile plaques. Neurofibrillary tangles are made of abnormal filaments (PHF) accumulating in neurons and mainly composed of a modified form of the microtubule-associated protein tau (PHF-tau). Senile plaques are composed of a cluster of dystrophic neurites surrounding an extracellular deposit of amyloid fibers made of a 42 amino-acid peptide (beta-amyloid peptide). The abnormal filaments contain the complete sequences of the different tau isoforms. The PHF-tau proteins can be distinguished from the normal tau proteins by the presence of several phosphorylated sites. One of these sites is phosphorylated by a calcium-calmodulin-dependent kinase. The relationship between PHF-tau and the cytoskeletal pathology in Alzheimer's disease is further discussed.
引用
收藏
页码：134 / 142
页数：9
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