DORSAL VENTRAL PATTERNING IN DROSOPHILA - DNA-BINDING OF SNAIL PROTEIN TO THE SINGLE-MINDED GENE

被引：90

作者：

KASAI, Y ^{[1
]}

NAMBU, JR ^{[1
]}

LIEBERMAN, PM ^{[1
]}

CREWS, ST ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,INST MOLEC BIOL,DEPT BIOL,LOS ANGELES,CA 90024

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 08期

关键词：

TRANSCRIPTIONAL CONTROL; ZINC FINGERS; CENTRAL NERVOUS SYSTEM DEVELOPMENT;

D O I：

10.1073/pnas.89.8.3414

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Drosophila snail gene is required for proper mesodermal development. Genetic studies suggest that it functions by repressing adjacent ectodermal gene expression including that of the single-minded (sim) gene. The snail gene encodes a protein with a zinc-finger motif, and here we report that the snail gene product is a sequence-specific DNA binding protein. The snail protein recognizes a 14-base-pair consensus sequence that is found nine times in a 2.8-kilobase sim regulatory region. These results provide evidence for the direct control of sim transcription by snail.

引用

页码：3414 / 3418

页数：5

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