Mechanistic studies on thiaminase I .1. The stereochemical course of the reaction

被引：9
|
作者：
Nicewonger, R [1 ]
Rammelsberg, A [1 ]
Costello, CA [1 ]
Begley, TP [1 ]
机构：
[1] CORNELL UNIV,DEPT CHEM,ITHACA,NY 14853
来源：
BIOORGANIC CHEMISTRY | 1995年 / 23卷 / 04期
关键词：
D O I：
10.1006/bioo.1995.1036
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Thiaminase I catalyzes the displacement of the thiazole moiety of thiamin by a wide variety of nucleophiles. In this paper, we demonstrate that this reaction proceeds with overall retention of stereochemistry. (C) 1995 Academic Press, Inc.
引用
收藏
页码：512 / 518
页数：7
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