Correlation between Magnetic Ressonance Image, Expression of Ki-67 and p53, and Prognosis in Astrocytomas

Objectives To evaluate the correlation between the expression of Ki-67 and p53 in astrocytomas grades II to IV, the characteristics of MRI and its prognosis. Methods This was a retrospective longitudinal cohort study of its kind that evaluated 45 patients. Prognosis was assessed by review of medical records. The immunohistochemical evaluation was performed at the Pathology Service of HB. The evaluation of MRI images was taken in the Radiology Department. The median survival of patients was 581.4 days in grade IV; 1704.8 days in grade III; 1044.8 days in grade II. For each grade, the following percentages of cells positive for Ki-67 and p53, respectively : 97.8% and 80% had a positive grade IV; 72.7% and 73.4% positivity in grade III; 70% and 80% in stage II positivity. There was statistical difference in Ki-67 between grades III and IV (P = 0.014). MRI showed 64% specificity and 100% sensitivity for the presence of tumor necrosis. Conclusion We conclude that the analysis of the positivity of Ki-67 and p53 expression does not allow correlation with patient survival, although both their frequency distributed similarly. MRI has moderate specificity in relation to pathological examination.