ANALYSIS OF T-HELPER SUBSETS OF PERIPHERAL BLOOD OF PATIENTS WITH CHRONIC HEPATITIS C EXPRESSING CHEMOKINE RECEPTORS CXCR3 AND CCR6 AND ACTIVATION MARKERS CD38 AND HLA-DR

被引：0

作者：

Elezov, D. S. ^{[1
]}

Kudryavtsev, I., V ^{[2
,3
,4
]}

Arsentieva, N. A. ^{[1
]}

Semenov, A., V ^{[1
]}

Esaulenko, E., V ^{[5
]}

Basina, V. V. ^{[5
]}

Areg, Totolian A. ^{[1
]}

机构：

[1] St Petersburg Pasteur Inst, St Petersburg, Russia

[2] Russian Acad Med Sci, North West Branch, Inst Expt Med, St Petersburg, Russia

[3] Far East Fed Univ, Vladivostok, Russia

[4] St Petersburg State Univ, St Petersburg, Russia

[5] St Petersburg State Pediat Med Univ, St Petersburg, Russia

来源：

INFEKTSIYA I IMMUNITET | 2013年 / 3卷 / 04期

关键词：

hepatitis C; T-helpers; chemokine receptors; activation markers; CXCR3; CCR6; CD38; HLA-DR;

D O I：

暂无

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In case of hepatitis C the adequate adaptive immune response depends on T-helper lymphocyte subsets and recruiting specific T cells in the site of infection. The purpose of the study was to assess changes in subpopulations of Thelper cells bearing chemokine receptor CXCR3 and CCR6 and activation markers CD38 and HLA-DR in peripheral blood of patients with chronic hepatitis C (n = 19) and healthy donors (n = 32). The T-helper phenotype was assessed by flow cytometry using a combination of monoclonal antibodies HLA-DR-FITC/CD38-PE/CD3-ECD/CCR6-PE-Cy7/ CXCR3-APC/CD4-APC-Cy7. It was demonstrated reduction of CD38(+) subset, increase of CXCR3+ and CCR6+ subsets of T-helper cells in particular CD3(+)CD4(+)CXCR3(+)CCR6(+) cells and importance of joint determination of the chemokine receptors CXCR3 and CCR6 and the activation markers CD38 and HLA-DR compared to their separate analysis in chronic hepatitis C.

引用

页码：327 / 334

页数：8

共 5 条

[1] Analysis of Populations of Memory T-Helper Cells Expressing CXCR3 and CCR6 Chemokine Receptors in Peripheral Blood of Patients with Chronic Viral Hepatitis C
Elezov, D. S.
Kudryavtsev, I. V.
Arsent'ev, N. A.
Basin, V. V.
Esaulenko, E. V.
Semenov, A. V.
Totolyan, A. A.
[J]. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2015, 160 (02) : 238 - 242
[2] Analysis of Populations of Memory T-Helper Cells Expressing CXCR3 and CCR6 Chemokine Receptors in Peripheral Blood of Patients with Chronic Viral Hepatitis C
D. S. Elezov
I. V. Kudryavtsev
N. A. Arsent’ev
V. V. Basin
E. V. Esaulenko
A. V. Semenov
A. A. Totolyan
[J]. Bulletin of Experimental Biology and Medicine, 2015, 160 : 238 - 242
[3] Chemokine Receptors CXCR3 and CCR6 and Their Ligands in the Liver and Blood of Patients with Chronic Hepatitis C
N. A. Arsent’eva
A. V. Semenov
N. E. Lyubimova
Yu. V. Ostankov
D. S. Elezo
I. V. Kudryavtsev
V. V. Basina
E. V. Esaulenko
K. V. Kozlov
K. V. Zhdanov
A. A. Totolyan
[J]. Bulletin of Experimental Biology and Medicine, 2015, 160 : 252 - 255
[4] Chemokine Receptors CXCR3 and CCR6 and Their Ligands in the Liver and Blood of Patients with Chronic Hepatitis C
Arsent'eva, N. A.
Semenov, A. V.
Lyubimova, N. E.
Ostankov, Yu. V.
Elezo, D. S.
Kudryavtsev, I. V.
Basina, V. V.
Esaulenko, E. V.
Kozlov, K. V.
Zhdanov, K. V.
Totolyan, A. A.
[J]. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2015, 160 (02) : 252 - 255
[5] Percentages of CD8+T cells expressing chemokine receptors CCR5, CXCR3, CCR4 and CXCCR4 are increased in synovial fluid as compared to peripheral blood in ankylosing spondylitis patients
Garcia-Latorre, Ethel Awilda
Rodarte-Gonzalez, Carlos
Jimenez-Zamudio, Luis
Dominguez-Lopez, Maria Lilia
Burgos-Vargas, Ruben
[J]. JOURNAL OF IMMUNOLOGY, 2006, 176 : S160 - S160

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