BIOMEDICAL MATERIALS BASED ON FULLERENES

被引：0

作者：

Fierascu, Radu Claudiu ^{[1
,2
]}

Dumitriu, Irina ^{[1
,2
]}

Ion, Rodica Mariana ^{[1
,2
]}

Bunghez, Raluca Ioana ^{[1
,2
]}

Neagu, Monica ^{[3
]}

Constantin, Carolina ^{[3
]}

Stavaru, Crina ^{[4
]}

机构：

[1] Valahia Univ, Mech Engn Mechatron & Robot Dept, 18-20 Unirii Blvd, Targoviste 130082, Romania

[2] Natl Res & Dev Inst Chem & Petrochem ICECHIM, Dept Anal, Bucharest 060021, Romania

[3] Victor Babes Natl Inst Pathol & Biomed Sci, Bucharest 050096, Romania

[4] INCDMI Cantacuzino, Bucharest 050096, Romania

来源：

SCIENTIFIC STUDY AND RESEARCH-CHEMISTRY AND CHEMICAL ENGINEERING BIOTECHNOLOGY FOOD INDUSTRY | 2011年 / 12卷 / 02期

关键词：

biomedical activity; biomedicine; characterization; fullerene materials; synthesis;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

biomedical techniques that exploit the chemical and physical properties of these unique structural carbon nanospheres. Their toxicity, demonstrated in vitro and in vivo is important for the characterization and the limitation of these applications. The photo toxicity of some fullerene molecules has been identified as a future therapeutic tool. The specific objective of the study is the synthesis of C60 derivatives. Starting from the characteristics of fullerene compounds, we tried to study in vitro C60 fullerene and some functionalized derivatives (C60 complexes with poly-vinyl pyrrolidone (PVP) and with the oxo-dimer (Fe-O)2TPP), experimental models in vitro with normal and tumor cells and investigation of their toxicological profile, in order to identify novel anti-neoplasic therapeutic devices.

引用

页码：147 / 154

页数：8

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