ENDOGENOUS NEUROTRANSMITTER ACTIVATES N-METHYL-D-ASPARTATE RECEPTORS ON DIFFERENTIATING NEURONS IN EMBRYONIC CORTEX

被引：67

作者：

BLANTON, MG

LOTURCO, JJ

KRIEGSTEIN, AR

机构：

[1] Neuro./Neurological Sci. Dept., Stanford University, Medical Center, Stanford

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1990年 / 87卷 / 20期

关键词：

cortical development; glutamate receptor; neuronal differentiation;

D O I：

10.1073/pnas.87.20.8027

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Before synapses form in embryonic turtle cerebral cortex, an endogenous neurotransmitter activates N-methyl-D-aspartate (NMDA) channels on neurons in the cortical plate. Throughout cortical development, these channels exhibit voltage-dependent Mg2+ blockade and are antagonized by D-2-amino-5-phosphonovaleric acid, a selective NMDA receptor antagonist. The activation in situ of these nonsynaptic NMDA channels demonstrates a potential physiological substrate for control of early neuronal differentiation.

引用

页码：8027 / 8030

页数：4

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