IDENTIFICATION OF AN EARLY-GROWTH-RESPONSE GENE ENCODING A NOVEL PUTATIVE PROTEIN-KINASE

被引:185
|
作者
SIMMONS, DL
NEEL, BG
STEVENS, R
EVETT, G
ERIKSON, RL
机构
[1] BETH ISRAEL HOSP,MOLEC MED UNIT,BOSTON,MA 02215
[2] HARVARD UNIV,DEPT CELLULAR & DEV BIOL,CAMBRIDGE,MA 02138
关键词
D O I
10.1128/MCB.12.9.4164
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Early-growth-response genes, also known as immediate-early genes, play important roles in regulating cell proliferation. We have identified a new type of early-growth-response gene product, a 77,811-Da putative serine/threonine kinase, which is highly inducible by serum and phorbol ester. mRNA encoding this putative kinase is markedly elevated within 1 h after treatment with mitogen, and this induction is synergistically increased by cycloheximide. Dexamethasone blocks serum induction of the kinase mRNA, as does transformation by v-Ki-ras. The kinase mRNA was detected in mouse brain, lung, and heart. This new putative kinase, which we term Snk, for serum-inducible kinase, showed similarity in its proposed catalytic domain to many other protein kinases; however, no other kinase showed enough sequence similarity with Snk to suggest the existence of a common function. Hence, Snk represents a new type of protein kinase involved in the early mitogenic response whose activity is transcriptionally and posttranscriptionally regulated.
引用
收藏
页码:4164 / 4169
页数:6
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