FLOW CYTOMETRIC ANALYSIS OF DNA PLOIDY IN LARGE CLEAVED CELL LYMPHOMAS

被引：3
|
作者：
AINE, R
LEHTINEN, T
LEHTINEN, M
BLANCO, G
APAJASARKKINEN, M
LEINIKKI, P
ALAVAIKKO, M
机构：
[1] TAMPERE UNIV,CENT HOSP,DEPT ONCOL,TAMPERE,FINLAND
[2] UNIV OULU,CENT HOSP,DEPT RADIOTHERAPY,SF-90220 OULU 22,FINLAND
[3] UNIV OULU,CENT HOSP,DEPT PATHOL,SF-90220 OULU 22,FINLAND
[4] UNIV TAMPERE,DEPT BIOMED SCI,TAMPERE,FINLAND
[5] NATL HLTH INST,HELSINKI,FINLAND
来源：
HEMATOLOGICAL ONCOLOGY | 1990年 / 8卷 / 06期
关键词：
NON-HODGKINS LYMPHOMAS; FLOW CYTOMETRY; DNA ANEUPLOIDY; DNA INDEX; S-PHASE FRACTION; SURVIVAL;
D O I：
10.1002/hon.2900080606
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The results of nuclear DNA content analysis of a series of 28 patients with large cleaved follicular centre cell non-Hodgkin's lymphomas (NHL) are reported. DNA aneuploidy was found in 11 (39 per cent) cases. The DNA indices of the DNA-aneuploid peaks ranged from 1.14 to 2.28. Seven (25 per cent) cases were tetraploid. DNA ploidy was not associated with prognosis. The percentage of S phase cells (SPF) ranged from 2.0 to 30.5 per cent (median 5.1 per cent). Lymphoma patients with SPF higher than 9.7 per cent had a worse survival rate than patients with lymphoma with less than 9.7 per cent S phase cells but the difference did not reach statistical significance. The results of the DNA ploidy and SPFF were comparable to those of intermediate and high grade malignancy NHLs.
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收藏
页码：339 / 346
页数：8
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