SYNTHESIS OF 5-OXO-1,2,3,5,6,7-HEXAHYDROIMIDAZO-[1,2-A]PYRIDINE-8-CARBONITRILES, 6-OXO-2,3,4,6,7,8-HEXAHYDRO-1H-PYRIDO[1,2-A]PYRIMIDINE-9-CARBONITRILES, AND 7-OXO-1,2,3,4,5,7,8,9-OCTAHYDROPYRIDO[1,2-A][1,3]DIAZEPINE-10-CARBONITRILES

被引：0

作者：

VICTORY, P ^{[1
]}

BUSQUETS, N ^{[1
]}

BORRELL, JI ^{[1
]}

TEIXIDO, J ^{[1
]}

DEALVARO, C ^{[1
]}

ARENAS, A ^{[1
]}

ALVAREZLARENA, A ^{[1
]}

PINIELLA, JF ^{[1
]}

机构：

[1] UNIV AUTONOMA BARCELONA,UNITAT CRISTALLOG,E-08193 BARCELONA,SPAIN

来源：

HETEROCYCLES | 1995年 / 41卷 / 10期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple method for the synthesis of the title compounds is described. Thus, alpha,beta-unsaturated esters (1) are transformed in the already described 2-methoxy-6-oxo-1,4,5,6-tetrahydropyridine-3-carbonitriles (3) which are treated with NH2(CH2)(n)NH2 (n = 2, 3, 4) to afford the corresponding bicyclic compounds (4, 5, and 6). The nitrogen bridged nature of these compounds is determined by an X-ray structure analysis of 4b. A ring opening-ring closure mechanism is proposed for the formation of structures (4-6) on the basis of the reaction between 3b and N-15,N-15'-ethylenediamine which afforded N-15,N-15'-4b.

引用

页码：2173 / 2179

页数：7

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