INHIBITORY EFFECT OF 17-BETA-ESTRADIOL ON PROSTAGLANDIN-E2-INDUCED PHOSPHOINOSITIDE HYDROLYSIS IN OSTEOBLAST-LIKE CELLS

被引：3

作者：

TOKUDA, H

YONEDA, M

OISO, Y

KOZAWA, O

机构：

[1] NAGOYA UNIV,SCH MED,DEPT INTERNAL MED 1,NAGOYA,AICHI 466,JAPAN

[2] AICHI PREFECTURAL COLONY,INST DEV RES,DEPT BIOCHEM,KASUGAI,AICHI 48003,JAPAN

来源：

PROSTAGLANDINS | 1992年 / 43卷 / 03期

关键词：

D O I：

10.1016/0090-6980(92)90095-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We examined the effect of estradiol on PGE2-induced phosphoinositide hydrolysis and cAMP production in cloned osteoblast-like MC3T3-E1 cells. 17-beta-Estradiol pretreatment significantly inhibited the formation of inositol phosphates induced by 10-mu-M PGE2 in a dose-dependent manner between 1 pM and 10 nM. This effect of 17-beta-estradiol was dependent on the time of pretreatment and submaximum inhibition was observed at 4 h. However, 17-beta-estradiol had little effect on the formation of inositol phosphates induced by 20 mM NaF, a GTP-binding protein activator. The cAMP production induced by PGE2 was not influenced by 17-beta-estradiol. These results suggest that 17-beta-estradiol modulates the signal transduction by PGE2 and that the effect seems to be exerted between PGE2 receptor and the GTP-binding protein coupled to phospholipase C in osteoblast-like MC3T3-E1 cells.

引用

页码：271 / 280

页数：10

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