Determination of eight bisphenol diglycidyl ethers in water by solid phase extraction-high performance liquid chromatography-tandem mass spectrometry

A solid phase extraction coupled with high performance liquid chromatography-tandem mass spectrometry (SPE HPLC MS/MS) method was developed for the determination of eight bisphenol diglycidyl ethers, including bisphenol A diglycidyl ether (BADGE) , bisphenol A (3-chloro-2-hydrmpropyl) glycidyl ether(BADGE center dot HCl) , bisphenol A bis (3-chloro-2-hydroxypropyl) ether (BADGE center dot 2HCl) , bisphenol A (2, 3-dihydrmpropyl) glycidyl ether (BADGE center dot H2O) , bisphenol A bis (2 , 3-dihydroxypropyl) ether(BADGE center dot 2H(2)O) , bisphenol A (3-chloro-2-hydroxypropyl) (2 , 3-dihydroxypropyl) ether(BADGE center dot HCl center dot H2O) , bisphenol F diglycidyl ether (BFDGE) and bisphenol F bis (3-chloro-2-hydroxypropyl) ether (BFDGE center dot 2HCl) in water. A total of ten samples were collected from the leaching of the coatings for drinking water supply system. Then, 200 mL exposure water was preconcentrated on C-18 solidphase extraction cartridge. The eight compounds were analyzed by liquid chromatographytandem mass spectrometry method on a C-18 column by the gradient elution with methanol, water and 5 mmoVL ammonium acetate as mobile phases in the multiple reaction monitoring ( MRM) scan mode. The external matrix standard solutions were used for the quantitative determination and the calibration curves of the eight compounds showed good linearity in the range of 0. 007-5. 00 ti.g/L with the correlation coefficients more than 0.999 0. The limits of quantification (LOQs) of the method were 7 -91 ng/L. The spiked recoveries ranged from 79. 1% to 101% with the relative standard deviations of 4. 0% -12%. The method is sensitive and accurate, and is applicable to the determination of bisphenol diglycidyl ethers in water.