INDUCTION OF DYSPNEA BY AEROSOL OF ENDOTHELIN-1 HISTAMINE OR METHACHOLINE IN THE CONSCIOUS GUINEA-PIG

被引：0
|
作者：
KOSHI, T [1 ]
ETOH, Y [1 ]
TORII, T [1 ]
WADA, Y [1 ]
HIRATA, M [1 ]
OHKUCHI, M [1 ]
OKABE, T [1 ]
机构：
[1] UNIV TOKYO, FAC MED, DEPT INTERNAL MED 3, BUNKYO KU, TOKYO 113, JAPAN
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 04期
关键词：
ENDOTHELIN-1; HISTAMINE; INDOMETHACIN; DYSPNEA; CONSCIOUS GUINEA PIG;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The inhalation of aerosol of endothelin-1 (ET-1) induced dyspneal behavior in conscious guinea pigs pretreated with histamine or methacholine inhalation, although it was not observed by the inhalation of ET-1 alone. The dyspneal response to the inhalation of ET-1/histamine was potently inhibited by indomethacin, but it was not affected by nifedipine or diphenhydramine.
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页码：1064 / 1065
页数：2
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