CHANGES IN PERIPHERAL-BLOOD LYMPHOCYTE SUBSET FREQUENCIES IN MYASTHENIA-GRAVIS PATIENTS ARE RELATED TO IMMUNOSUPPRESSION

被引：11
|
作者：
CROSTI, F [1 ]
ARMANINI, M [1 ]
CONFALONIERI, P [1 ]
ANTOZZI, C [1 ]
MANTEGAZZA, R [1 ]
机构：
[1] IST NAZL NEUROL C BESTA,DIV MALATTIE NEUROMUSCOLARI,I-20133 MILAN,ITALY
来源：
JOURNAL OF NEUROLOGY | 1994年 / 241卷 / 04期
关键词：
MYASTHENIA GRAVIS LYMPHOCYTE SUBSETS; FLOW CYTOMETRY; STEROIDS;
D O I：
10.1007/BF00863771
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Surface antigens on peripheral blood lymphocytes from myasthenia gravis patients were investigated. The expression of DR(+) and CD8(+)/DR(+) T lymphocytes was increased and the expression of CD4(+) T cells reduced. Neither thymectomy, clinical condition nor anti-acetylcholine receptor antibody titre correlated with any of the changes in peripheral blood lymphocyte subsets observed. However, immunosuppressive therapy correlated with the significant reduction in CD4(+) and CD2(+)/CD4(+) T cells in these patients.
引用
收藏
页码：218 / 222
页数：5
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