The clinical problem of unrelieved pain has received much attention over the previous decade with a major focus on cancer pain and acute postoperative pain. Organizations such as the World Health Organization (WHO), the National Cancer Institute, the American Pain Society (APS), and others have addressed the previously neglected areas of pain assessment, pharmacologic treatment, and the knowledge and attitudes of health-care providers. Health-policy issues related to pain, including areas of cost, access to care, regulatory perspectives and ethical and legal issues, have likewise been neglected. To explore the costs associated with pain, the following framework has been developed through the Agency for Health Care Policy and Research (AHCPR) pain panel. This 13-point framework is an attempt to isolate specific cost issues, identify what is known in these areas, and address implications for future research. A brief synopsis of these 13 areas of cost analysis is provided including comments regarding work in progress by the panel and directions for future health-policy research related to pain management.