SOLID-PHASE PEPTIDE-SYNTHESIS WITHOUT SIDE-CHAIN HYDROXYL PROTECTION OF THREONINE

被引：0
|
作者：
FISCHER, PM
RETSON, KV
TYLER, MI
HOWDEN, MEH
机构：
[1] CSIRO,DEAKIN RES LTD,DIV FOOD PROC,N RYDE,NSW 2113,AUSTRALIA
[2] DEAKIN UNIV,DEPT BIOL SCI,GEELONG,VIC 3217,AUSTRALIA
来源：
INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH | 1991年 / 38卷 / 05期
关键词：
SOLID-PHASE PEPTIDE SYNTHESIS; THREONINE HYDROXYL PROTECTION;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A peptide containing four threonine residues was synthesised by the solid-phase method using fluorenylmethoxycarbonylamino acid reactive esters or coupling by preactivation with 1-hydroxybenzotriazole and Castro's reagent. In two separate experiments the synthesis was carried out with or without protection of the side-chain hydroxyl group of threonine as the tert.-butyl ether. Comparison of the crude peptides after deprotection and detachment from the synthesis resin suggests that side-chain protection of threonine is unnecessary under the synthetic conditions employed.
引用
收藏
页码：491 / 493
页数：3
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