THE ROLE OF HEMATOPOIETIC GROWTH-FACTORS IN BONE-MARROW TRANSPLANTATION

Bone marrow transplantation (BMT) is being increasingly used for treating a large number of diseases. The recent availability of haematopoietic growth factors (HGFs) for therapeutic purposes has offered a powerful tool in order to overcome one of the most important BMT-related complications, namely severe myelosuppression. This article, besides an overview on the main results achieved with the clinical use of HGFs for haematopoietic reconstitution after BMT, also deals with some innovative applications of these molecules in BMT setting, as their use for peripheral stem cell transplantation and bone marrow failure after BMT.