QUANTITATIVE-DETERMINATION OF E-DOXEPIN AND Z-DOXEPIN AND E-DESMETHYLDOXEPIN AND Z-DESMETHYLDOXEPIN BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：12
|
作者：
ADAMCZYK, M [1 ]
FISHPAUGH, JR [1 ]
HARRINGTON, C [1 ]
机构：
[1] ABBOTT LABS,ABUSED DRUGS & TOXICOL,ABBOTT PK,IL 60064
来源：
THERAPEUTIC DRUG MONITORING | 1995年 / 17卷 / 04期
关键词：
CIS-DOXEPIN; TRANS-DOXEPIN; CIS-DESMETHYLDOXEPIN; TRANS-DESMETHYLDOXEPIN; ANTIDEPRESSANTS; PLASMA LEVELS; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC SEPARATION;
D O I：
10.1097/00007691-199508000-00010
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
A high-performance liquid chromatographic (HPLC) method was developed for the quantitative, simultaneous determination of the following four compounds in serum: E-doxepin, Z-doxepin, E-desmethyldoxepin, and Z-desmethyldoxepin. A 3-mu m analytical silica column (6 x 100 mm) was employed with the mobile phase 0.025 M phosphate:acetonitrile:n-nonylamine (80:20:1). This HPLC method allows for the accurate measurement of all four isomeric compounds.
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页码：371 / 376
页数：6
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