Plasminogen activation at the cell surface: a functional crossroad of cell migration-associated pathways

被引：0
|
作者：
Teesalu, T [1 ]
Myohanen, H [1 ]
Vaheri, A [1 ]
机构：
[1] Univ Helsinki, Haartman Inst, FIN-00014 Helsinki, Finland
来源：
MOLECULAR MECHANISMS OF TRANSCELLULAR SIGNALING: FROM MEMBRANE RECEPTORS TO TRANSCRIPTION FACTORS | 1999年 / 309卷
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D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cell migration is a multistep process, which requires precise coordination of proteolytic, adhesive and motogenic pathways. The role of plasminogen activators, in particular urokinase-type plasminogen activator (uPA), in pericellular proteolysis is well established. Furthermore, novel information indicates the involvement of the uPA system in cell adhesion and chemotactic behavior. Thus the uPA-system plays a unique role in integrating different aspects of cell migratory behavior and coordinating cell invasion.
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页码：290 / 295
页数：6
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