FORMATION OF BENZO[A]PYRENE-DNA ADDUCTS IN BLOOD MONOCYTES FROM LUNG-CANCER PATIENTS WITH A FAMILIAL HISTORY OF LUNG-CANCER

被引：8
|
作者：
NOWAK, D
MEYER, A
SCHMIDTPREUSS, U
GATZEMEIER, U
MAGNUSSEN, H
RUDIGER, HW
机构：
[1] UNIV HAMBURG,ORDINARIAT ARBEITSMED,ARBEITSGRP TOXIKOGENET,ADOLPH SCHONFELDER STR 5,W-2000 HAMBURG 76,GERMANY
[2] KRANKENHAUS GROSSHANSDORF,ZENTRUM PNEUMOL & THORAXCHIRURG,W-2070 GROSSHANSDORF,GERMANY
来源：
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 1992年 / 118卷 / 01期
关键词：
LUNG CANCER; GENETIC PREDISPOSITION; FAMILIAL CANCER; BENZO[ALPHA]PYRENE; DNA ADDUCTS;
D O I：
10.1007/BF01192314
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The in vitro formation of benzo[a]pyrene-DNA adducts was determined in peripheral blood monocytes of 22 lung cancer patients with at least one first-degree relative with lung cancer and compared to results obtained in 30 healthy controls. In patients, the mean (SEM) adduct formation was 2.8 (0.3) fmol/mu-g DNA as compared to 2.1 (0. 1) fmol/mu-g in controls (p < 0. 05), and it was independent of age and smoking habits. These findings support the hypothesis that carcinogen-DNA adduct formation may be one factor of a constitutionally enhanced lung cancer risk.
引用
收藏
页码：67 / 71
页数：5
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