Biomarkers for renal transplantation: where are we?

被引:7
|
作者
Ge, Fangmin [1 ,2 ]
Dai, Qiaoding [3 ]
Gong, Weihua [4 ]
机构
[1] Zhejiang Univ, Affiliated Hosp 2, Hosp Adm Off, Sch Med,Dept Med, Hangzhou, Zhejiang, Peoples R China
[2] Health Bur Shangcheng Dist Hangzhou, Hangzhou, Zhejiang, Peoples R China
[3] Zhejiang Chinese Med Univ, Affiliated Hosp 1, Dept Rheumatism & Immunol, Hangzhou, Zhejiang, Peoples R China
[4] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Transplant Int Res Ctr,Dept Surg, Jiefang Rd 88, Hangzhou 310009, Zhejiang, Peoples R China
基金
中国国家自然科学基金;
关键词
biomarkers; renal transplantation; diagnostic techniques; reversible; preemptive treatment;
D O I
10.2147/IJNRD.S39806
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Although surgical techniques, post-transplant care medicine, and immunosuppressants have been greatly improved, permanent acceptance of renal allograft remains a clinical challenge owing to the appearance of various influencing factors. To predict graft dysfunction, development of noninvasive biomarkers is becoming a highlighted research topic in the field of renal transplantation, which provides a possibility for physicians to give preemptive rescue treatment. From the viewpoint of diagnostic techniques, repetitive sampling is prerequisite to identify applicable biomarkers in the clinic. Early biomarkers can be used to dynamically monitor renal graft status and accurately predict transplant outcome independent of various confounders. This review highlights recent studies on the predictive value of biomarkers and methods to quantify biomarkers for monitoring kidney transplant. It is important to analyze and compare different biomarkers for living, and nonliving donors. Analysis of identified clinically relevant biomarkers will advance our understanding of distinct molecular and cellular mechanisms of transplantation and provide insight into developing novel potential approaches to induce transplant tolerance.
引用
收藏
页码:187 / 191
页数:5
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