LIDOCAINE REDUCES THE HYPOXIA-INDUCED RELEASE OF AN EXCITATORY AMINO-ACID ANALOG FROM RAT STRIATAL, SLICES IN SUPERFUSION

被引：8

作者：

DIAZ, L ^{[1
]}

GOMEZ, A ^{[1
]}

BUSTOS, G ^{[1
]}

机构：

[1] PONTIFICIA UNIV CATOLICA CHILE, FAC CIENCIAS BIOL, FARMACOL BIOQUIM LAB, SANTIAGO, CHILE

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1995年 / 19卷 / 05期

关键词：

CEREBRAL HYPOXIA; EXCITATORY AMINO ACIDS; EXCITOTOXICITY; LIDOCAINE;

D O I：

10.1016/0278-5846(95)00122-C

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. Lidocaine has been extensively investigated as a potential neuroprotective drug against ischemia-induced neurodegeneration without reaching any satisfactory conclusion. 2. The present work evaluates the effect of lidocaine -17 mu M- on the hypoxia-induced release of tritiated D-aspartate from rat striatal slices in superfusion. 3. Hypoxia resulted in a significant increase in the amount of D-aspartate released from striatal slices preloaded with the tritiated excitatory amino acid analog. 4. The addition of lidocaine to the superfusion solution resulted in a drastic reduction in the amount of D-aspartate release evoked by hypoxia, rendering it close to normal values.

引用

页码：943 / 953

页数：11

共 50 条

[1] THE EFFECT OF FLUOROCITRATE ON TRANSMITTER AMINO-ACID RELEASE FROM RAT STRIATAL SLICES
PAULSEN, RE
CONTESTABILE, A
VILLANI, L
FONNUM, F
[J]. NEUROCHEMICAL RESEARCH, 1988, 13 (07) : 637 - 641
[2] CHARACTERIZATION OF THE EXCITATORY AMINO-ACID RECEPTOR-MEDIATED RELEASE OF [H-3] ACETYLCHOLINE FROM RAT STRIATAL SLICES
LEHMANN, J
SCATTON, B
[J]. BRAIN RESEARCH, 1982, 252 (01) : 77 - 89
[3] EXCITATORY AMINO-ACID ANTAGONISTS AND ENDOGENOUS ASPARTATE AND GLUTAMATE RELEASE FROM RAT HIPPOCAMPAL SLICES
CONNICK, JH
STONE, TW
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1988, 93 (04) : 863 - 867
[4] EXCITATORY AMINO-ACID RELEASE FROM RAT HIPPOCAMPAL SLICES AS A CONSEQUENCE OF FREE-RADICAL FORMATION
PELLEGRINIGIAMPIETRO, DE
CHERICI, G
ALESIANI, M
CARLA, V
MORONI, F
[J]. JOURNAL OF NEUROCHEMISTRY, 1988, 51 (06) : 1960 - 1963
[5] RELEASE OF ENDOGENOUS DOPAMINE, 3,4-DIHYDROXYPHENYLACETIC ACID, AND AMINO-ACID TRANSMITTERS FROM RAT STRIATAL SLICES
FLINT, RS
MURPHY, JM
MCBRIDE, WJ
[J]. NEUROCHEMICAL RESEARCH, 1985, 10 (04) : 515 - 527
[6] Adenosine A(1) receptors mediate hypoxia-induced inhibition of electrically evoked transmitter release from rat striatal slices
Jin, SY
Fredholm, BB
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1997, 329 (2-3) : 107 - 113
[7] MET-ENKEPHALIN SELECTIVELY INCREASES THE SPONTANEOUS RELEASE OF AMINO-ACID NEUROTRANSMITTERS FROM RAT STRIATAL SLICES
ARNERIC, SP
MEELEY, MP
REIS, DJ
[J]. NEUROSCIENCE LETTERS, 1986, 66 (01) : 73 - 78
[8] EXCITATORY AMINO-ACIDS RELEASE ENDOGENOUS ACETYLCHOLINE FROM RAT STRIATAL SLICES - REGULATION BY GAMMA-AMINOBUTYRIC-ACID
ALBERCH, J
ARENAS, E
ARROYOS, RS
MARSAL, J
[J]. NEUROCHEMISTRY INTERNATIONAL, 1990, 17 (01) : 107 - 116
[9] AMPA- and kainate-receptors differentially mediate excitatory amino acid-induced dopamine and acetylcholine release from rat striatal slices
Jin, S
[J]. NEUROPHARMACOLOGY, 1997, 36 (11-12) : 1503 - 1510
[10] PENTOBARBITAL AS AN EXCITATORY AMINO-ACID ANTAGONIST IN SLICES OF RAT CEREBRAL-CORTEX
HARRISON, NL
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1985, 360 (MAR): : P38 - P38

← 1 2 3 4 5 →