PROTECTION OF GUINEA-PIGS AGAINST FOOT-AND-MOUTH-DISEASE VIRUS BY IMMUNIZATION WITH A PHOE FMDV HYBRID PROTEIN

被引：13
|
作者：
AGTERBERG, M
ADRIAANSE, H
BARTELING, S
VANMAANEN, K
TOMMASSEN, J
机构：
[1] STATE UNIV UTRECHT,INST MOLEC BIOL & MED BIOTECHNOL,PADUALAAN 8,3584 CH UTRECHT,NETHERLANDS
[2] CENT VET INST,8221 RA LELYSTAD,NETHERLANDS
[3] STATE UNIV UTRECHT,DEPT MOLEC CELL BIOL,3584 CH UTRECHT,NETHERLANDS
来源：
VACCINE | 1990年 / 8卷 / 05期
关键词：
carrier system; foot-and-mouth disease virus; PhoE protein; vaccine;
D O I：
10.1016/0264-410X(90)90242-E
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A hybrid protein was constructed containing two antigenic determinants of the structural protein VPI of foot-and-mouth disease virus, inserted in a cell surface-exposed region of Escherichia coli outer membrane protein PhoE. Immunization of guinea-pigs with partially purified protein resulted in high levels of neutralizing antibodies and complete protection against challenge with the virus. © 1990.
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页码：438 / 440
页数：3
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