INHIBITION OF MAMMALIAN HEPATIC GLUTATHIONE S-TRANSFERASES BY ACETYLENIC FATTY-ACIDS

被引：6
|
作者：
DATTA, K [1 ]
KULKARNI, AP [1 ]
机构：
[1] UNIV S FLORIDA,COLL PUBL HLTH,FLORIDA TOXICOL RES CTR,TAMPA,FL 33612
来源：
TOXICOLOGY LETTERS | 1994年 / 73卷 / 02期
关键词：
GLUTATHIONE S-TRANSFERASE; INHIBITION; LIPOXYGENASE INHIBITORS; ACETYLENIC FATTY ACIDS;
D O I：
10.1016/0378-4274(94)90105-8
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Micromolar concentrations of 2 classical inhibitors of lipoxygenase, 5,8,11 -eicosatriynoic acid (ETI) and 5,8,11,14-eicosatetraynoic acid (ETYA), were found to cause a significant inhibition of the mixture of isozymes of affinity purifed rat and human liver glutathione S-transferase (GST) with activity towards 1-chloro-2,4-dinitrobenzene (CDNB). ETI was a more potent inhibitor of both rat and human liver GST than ETYA. Analysis of kinetic data suggested noncompetitive inhibition of human liver GST by ETI towards reduced glutathione and CDNB. ETI also inhibited the hepatic GST activity towards 1,2-dichloro-4-nitrobenzene, p-nitrobenzyl chloride and 4-nitropyridine N-oxide.
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页码：157 / 165
页数：9
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