ROLE OF REPEATED EXPOSURE TO MORPHINE IN DETERMINING ITS AFFECTIVE PROPERTIES - PLACE AND TASTE CONDITIONING STUDIES IN RATS

被引：122
|
作者：
GAIARDI, M
BARTOLETTI, M
BACCHI, A
GUBELLINI, C
COSTA, M
BABBINI, M
机构：
[1] Institute of Pharmacology, University of Bologna, Bologna
来源：
PSYCHOPHARMACOLOGY | 1991年 / 103卷 / 02期
关键词：
SENSITIZATION TO DRUG REWARD; MORPHINE; PLACE CONDITIONING; TASTE CONDITIONING; ABUSE POTENTIAL; RAT;
D O I：
10.1007/BF02244201
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Male Sprague Dawley rats were injected daily with saline (morphine naive rats) or 20 mg/kg morphine (morphine experienced rats), starting at least 12 days before training. Subsequent place and taste conditioning indicated that 2.5 mg/kg morphine caused a significant increase in the amount of time spent on the least preferred side by morphine experienced but not by morphine naive rats; furthermore, saccharin consumption was markedly decreased and slightly increased by 10-20 mg/kg morphine in naive and experienced rats, respectively. It was concluded that morphine experience enhances the reinforcing efficacy of morphine and broadens the conditions under which the drug is reinforcing; thus it possibly increases morphine abuse potential.
引用
收藏
页码：183 / 186
页数：4
相关论文
共 12 条
  • [1] The aversive properties of acute morphine dependence persist 48 h after a single exposure to morphine - Evaluation by taste and place conditioning
    Parker, LA
    Cyr, JA
    Santi, AN
    Burton, PD
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2002, 72 (1-2) : 87 - 92
  • [2] Motivational properties of buprenorphine as assessed by place and taste conditioning in rats
    Gaiardi, M
    Bartoletti, M
    Bacchi, A
    Gubellini, C
    Babbini, M
    PSYCHOPHARMACOLOGY, 1997, 130 (02) : 104 - 108
  • [3] Motivational properties of buprenorphine as assessed by place and taste conditioning in rats
    M. Gaiardi
    M. Bartoletti
    A. Bacchi
    C. Gubellini
    M. Babbini
    Psychopharmacology, 1997, 130 : 104 - 108
  • [4] A history of morphine-induced taste aversion learning fails to affect morphine-induced place preference conditioning in rats
    King, Heather E.
    Riley, Anthony L.
    LEARNING & BEHAVIOR, 2013, 41 (04) : 433 - 442
  • [5] A history of morphine-induced taste aversion learning fails to affect morphine-induced place preference conditioning in rats
    Heather E. King
    Anthony L. Riley
    Learning & Behavior, 2013, 41 : 433 - 442
  • [6] Novelty preference predicts place preference conditioning to morphine and its oral consumption in rats
    Pelloux, Yann
    Costentin, Jean
    Duterte-Boucher, Dominique
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2006, 84 (01) : 43 - 50
  • [7] NALOXONE AND MORPHINE REINFORCING PROPERTIES REVEALED BY PLACE CONDITIONING IN RATS - EVIDENCE OF ADDITIVE EFFECTS
    GAIARDI, M
    BARTOLETTI, M
    GUBELLINI, C
    BACCHI, A
    BABBINI, M
    PSYCHOPHARMACOLOGY, 1986, 89 (04) : S15 - S15
  • [8] Pre-exposure to cocaine or morphine attenuates taste avoidance conditioning in adolescent rats: Drug specificity in the US pre-exposure effect
    Clasen, Matthew M.
    Hempel, Briana J.
    Riley, Anthony L.
    DEVELOPMENTAL PSYCHOBIOLOGY, 2017, 59 (04) : 486 - 494
  • [9] Conditioning following repeated exposure to MDMA in rats: Role in the maintenance of MDMA self-administration
    Daniela, Evangeline
    Gittings, David
    Schenk, Susan
    BEHAVIORAL NEUROSCIENCE, 2006, 120 (05) : 1144 - 1150
  • [10] Adolescent delta-9-tetrahydrocannabinol (THC) exposure fails to affect THC-induced place and taste conditioning in adult male rats
    Wakeford, Alison G. P.
    Flax, Shaun M.
    Pomfrey, Rebecca L.
    Riley, Anthony L.
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2016, 140 : 75 - 81
12