CLOBETASONE-17-BUTYRATE AND CATARACT P-13, H-1, C-13 NMR-STUDY

被引：0
|
作者：
PESCOSOLIDO, N
ACCORINTI, M
DELFINI, M
GUGLIELMELLI, F
LAZZARI, M
MANETTI, C
MICCHELI, A
机构：
[1] Department of Physiopathological Optics, University of Rome ‘La Sapienza’, Rome
[2] Department of Chemistry, University of Rome ‘La Sapienza’, Rome
[3] Policlinico Umberto I, Universita’ Degli Studi di Roma ‘La Sapienza’, Rome, 00161, Viale del Policlinico
来源：
DRUG INVESTIGATION | 1993年 / 6卷 / 02期
关键词：
D O I：
10.1007/BF03258457
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects on metabolism by a synthetic corticosteroid drug, clobetasone-17-butyrate, were investigated in rabbit lenses by P-31, H-1, C-13 nuclear magnetic resonance spectroscopy. No variations were observed in the levels of sorbitol, sorbitol 3-P, alpha-glycerophosphate, fructose 3-P or myoinositol. Moreover, clobetasone-17-butyrate was not shown to influence the active transport of amino acids nor to alter blood sugar levels. These results indicate that clobetasone-17-butyrate instillation does not induce side effects in the rabbit lens, as has been reported following dexamethasone treatment.
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页码：83 / 89
页数：7
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