CHEMICAL AND STEREOCHEMICAL ASPECTS OF PROPRANOLOL METABOLISM - DIASTEREOMERIC 1-(1-HYDROXY-2-PROPYLAMINO)-3-(1-NAPHTHOXY)-2-PROPANOLS PRODUCED BY RAT-LIVER MICROSOMAL OMEGA-HYDROXYLATION

被引：5

作者：

SHETTY, HU ^{[1
]}

NELSON, WL ^{[1
]}

机构：

[1] UNIV WASHINGTON,SCH PHARM,DEPT MED CHEM,SEATTLE,WA 98195

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1986年 / 29卷 / 10期

关键词：

D O I：

10.1021/jm00160a034

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：2004 / 2008

页数：5

共 16 条

[1] CHEMICAL ASPECTS OF METOPROLOL METABOLISM - ASYMMETRIC-SYNTHESIS AND ABSOLUTE-CONFIGURATION OF THE 3-[4-(1-HYDROXY-2-METHOXYETHYL)PHENOXY]-1-(ISOPROPYLAMINO)-2-PROPANOLS, THE DIASTEREOMERIC BENZYLIC HYDROXYLATION METABOLITES
SHETTY, HU
NELSON, WL
JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (01) : 55 - 59
[2] N-DEALKYLATION OF PROPRANOLOL - TRAPPING OF THE 3-(1-NAPHTHOXY)-2-HYDROXYPROPIONALDEHYDE FORMED IN RAT-LIVER MICROSOMES
CHEN, CH
NELSON, WL
DRUG METABOLISM AND DISPOSITION, 1982, 10 (03) : 277 - 278
[3] POTENTIAL ANTIDEPRESSANTS AND TRANQUILIZERS - SYNTHESIS OF SOME 9-(AMINOALKOXY)-2,3,6,7-TETRAHYDRO-1H,5H-BENZO[IJ] QUINOLIZINES AND 1-(SUBSTITUTED AMINO)-3-(1-NAPHTHOXY)-2-PROPANOLS
VEJDELEK, Z
PROTIVA, M
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1990, 55 (05) : 1290 - 1296
[4] CHEMICAL ASPECTS OF PROPRANOLOL METABOLISM - SYNTHESIS AND IDENTIFICATION OF 3-(4-HYDROXY-1-NAPHTHOXY)PROPANE-1,2-DIOL AS A METABOLITE OF PROPRANOLOL IN THE DOG, IN MAN AND IN THE RAT-LIVER 9000G SUPERNATANT FRACTION
GUPTE, SM
BARTELS, MJ
KERR, BM
LAGANIERE, S
SILBER, BM
NELSON, WL
RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY, 1983, 42 (02): : 235 - 244
[5] SYNTHESIS AND IDENTIFICATION OF 3-(4-HYDROXY-1-NAPHTHOXY)LACTIC ACID AS A METABOLITE OF PROPRANOLOL IN THE RAT, IN MAN, AND IN THE RAT-LIVER 9000G SUPERNATANT FRACTION
TALAAT, RE
NELSON, WL
DRUG METABOLISM AND DISPOSITION, 1986, 14 (02) : 202 - 207
[6] HYDROXYLATION OF CARCINOSTATIC 1-(2-CHLOROETHYL)-3-CYCLOHEXYL-1-NITROSOUREA (CCNU) BY RAT-LIVER MICROSOMES
MAY, HE
BOOSE, R
REED, DJ
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1974, 57 (02) : 426 - 433
[7] CHEMICAL ASPECTS OF PROPRANOLOL METABOLISM - 1,1-DIETHOXY-3-(1-NAPHTHOXY)-2-PROPANOL AND RELATED RING-CLOSURE PRODUCTS CIS AND TRANS-4-ETHOXY-3-HYDROXY-3,4-DIHYDRO-2H-NAPHTHO[1,2-B]PYRAN
CHEN, CH
NELSON, WL
JOURNAL OF PHARMACEUTICAL SCIENCES, 1983, 72 (08) : 863 - 865
[8] SYNTHESIS AND IDENTIFICATION OF PRODUCTS DERIVED FROM THE METABOLISM OF THE CARCINOSTATIC 1-(2-CHLOROETHYL)-3-(TRANS-4-METHYLCYCLOHEXYL)-1-NITROSOUREA BY RAT-LIVER MICROSOMES
MAY, HE
KOHLHEPP, SJ
BOOSE, RB
REED, DJ
CANCER RESEARCH, 1979, 39 (03) : 762 - 772
[9] 1-HYDROXY-3-METHYLCHOLANTHRENE AND 2-HYDROXY-3-METHYLCHOLANTHRENE - REGIOSELECTIVE AND STEREOSELECTIVE FORMATIONS IN THE METABOLISM OF 3-METHYLCHOLANTHRENE AND ENANTIOSELECTIVE DISPOSITION IN RAT-LIVER MICROSOMES
SHOU, MG
YANG, SK
CARCINOGENESIS, 1990, 11 (06) : 933 - 940
[10] METABOLISM OF 4-(3-CYCLOHEXYLPROPIONYL)-1-(2-ETHOXYPHE PIPERAZINE (D-16120) BY RAT-LIVER MICROSOMES
CAPUTO, O
ROCCO, F
GROSA, G
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 1994, 19 (04) : 303 - 310

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