ENDOTHELIAL NITRIC-OXIDE ATTENUATES VASOCONSTRICTOR RESPONSES TO NERVE-STIMULATION AND NORADRENALINE IN THE RAT TAIL ARTERY

被引：49
|
作者：
VO, PA
REID, JJ
RAND, MJ
机构：
[1] Department of Pharmacology, University of Melbourne, Melbourne
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 199卷 / 01期
关键词：
NITRIC OXIDE (NO); NG-NITRO-L-ARGININE; SYMPATHETIC NERVE STIMULATION; NORADRENALINE; TAIL ARTERY (RAT);
D O I：
10.1016/0014-2999(91)90647-9
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of the nitric oxide synthesis inhibitor, N(G)-nitro-L-arginine (NOLA), have been examined in perfused segments of rat tail artery. NOLA (1 and 10-mu-M) significantly enhanced the vasoconstrictor responses to perivascular nerve stimulation (5 Hz, 10 s) and noradrenaline (10 ng). The enhancing effects of NOLA were prevented by L-arginine, but not by D-arginine, and were absent in endothelium-denuded artery segments. The results suggest that nitric oxide derived from endothelial cells attenuates vasoconstrictor responses to both nerve stimulation and noradrenaline.
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页码：123 / 125
页数：3
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