GENTAMICIN AND VANCOMYCIN REMOVAL BY CONTINUOUS VENOVENOUS HEMOFILTRATION

被引：9
|
作者：
THOMSON, AH
GRANT, AC
RODGER, RSC
HUGHES, RL
机构：
[1] STOBHILL GEN HOSP,INTENS THERAPY UNIT,GLASGOW G21 3UW,SCOTLAND
[2] WESTERN INFIRM & ASSOCIATED HOSP,RENAL UNIT,GLASGOW G11 6NT,SCOTLAND
来源：
DICP-THE ANNALS OF PHARMACOTHERAPY | 1991年 / 25卷 / 02期
关键词：
D O I：
10.1177/106002809102500203
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The dispositions and dose requirements for vancomycin and gentamicin were investigated in a 58-year-old man who was receiving long-term continuous venovenous hemofiltration. Estimates of clearance were obtained using a Bayesian parameter estimation program and stayed remarkably consistent throughout the therapy. Single daily doses of both vancomycin and gentamicin generally maintained the profiles for both drugs around the target ranges of peak 5-10 mg/L (gentamicin) and 25-40 mg/L (vancomycin) and trough < 2 mg/L (gentamicin) and < 10 mg/L (vancomycin).
引用
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页码：127 / 129
页数：3
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