A Mathematical Model for Thermosensitive Liposomal Delivery of Doxorubicin to Solid Tumour

被引:42
|
作者
Zhan, Wenbo [1 ]
Xu, Xiao Yun [1 ]
机构
[1] Imperial Coll London, South Kensington Campus, Dept Chem Engn, London SW7 2AZ, England
基金
英国工程与自然科学研究理事会;
关键词
D O I
10.1155/2013/172529
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effectiveness of anticancer treatments is often hampered by the serious side effects owing to toxicity of anticancer drugs and their undesirable uptake by healthy cells in vivo. Thermosensitive liposome- mediated drug delivery has been developed as part of research efforts aimed at improving therapeutic efficacy while reducing the associated side effect. Since multiple steps are involved in the transport of drug- loaded liposomes, drug release, and its uptake, mathematical models become an indispensible tool to analyse the transport processes and predict the outcome of anticancer treatment. In this study, a computational model is developed which incorporates the key physical and biochemical processes involved in drug delivery and cellular uptake.the model has been applied to idealized tumour geometry, and comparisons are made between continuous infusion of doxorubicin and thermosensitive liposome- mediated delivery. Results show that thermosensitive liposome- mediated delivery performs better in reducing drug concentration in normal tissues, which may help lower the risk of associated side effects. Compared with direct infusion over a 2- hour period, thermosensitive liposome delivery leads to a much higher peak intracellular concentration of doxorubicin, which may increase cell killing in tumour thereby enhancing the therapeutic effect of the drug.
引用
收藏
页数:13
相关论文
共 50 条
  • [1] A systematic study of temperature sensitive liposomal delivery of doxorubicin using a mathematical model
    Liu, Cong
    Xu, Xiao Yun
    [J]. COMPUTERS IN BIOLOGY AND MEDICINE, 2015, 60 : 107 - 116
  • [2] Drug development of lyso-thermosensitive liposomal doxorubicin: Combining hyperthermia and thermosensitive drug delivery
    Borys, Nicholas
    Dewhirst, Mark W.
    [J]. Advanced Drug Delivery Reviews, 2021, 178
  • [3] Drug development of lyso-thermosensitive liposomal doxorubicin: Combining hyperthermia and thermosensitive drug delivery
    Borys, Nicholas
    Dewhirst, Mark W.
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 2021, 178
  • [4] Delivery of Doxorubicin to Solid Tumors Using Thermosensitive Liposomes
    Tazina, Elizaveta V.
    Polozkova, Alevtina P.
    Ignatieva, Elena V.
    Orlova, Olga L.
    Mescherikova, Valeria V.
    Wainson, Adolf A.
    Oborotova, Natalia A.
    Baryshnikov, Anatoliy Yu.
    [J]. ADVANCES IN MATERIAL DESIGN FOR REGENERATIVE MEDICINE, DRUG DELIVERY AND TARGETING/IMAGING, 2009, 1140 : 105 - 110
  • [5] Towards a multiphysics modelling framework for thermosensitive liposomal drug delivery to solid tumour combined with focused ultrasound hyperthermia
    Wenbo Zhan
    Wladyslaw Gedroyc
    Xiao Yun Xu
    [J]. Biophysics Reports, 2019, 5 (01) : 43 - 59
  • [6] A Unified Mathematical Model for Nano-Liposomal Drug Delivery to Solid Tumors
    Asemani, Davud
    Haemmerich, Dieter
    [J]. IEEE TRANSACTIONS ON NANOBIOSCIENCE, 2018, 17 (01) : 3 - 11
  • [7] A mathematical model for comparison of bolus injection, continuous infusion, and liposomal delivery of doxorubicin to tumor cells
    El-Kareh, AW
    Secomb, TW
    [J]. NEOPLASIA, 2000, 2 (04): : 325 - 338
  • [8] Extracorporeal Removal of Thermosensitive Liposomal Doxorubicin from Systemic Circulation after Tumor Delivery to Reduce Toxicities
    Motamarry, Anjan
    Wolfe, A. Marissa
    Ramajayam, Krishna K.
    Pattanaik, Sanket
    Benton, Thomas
    Peterson, Yuri
    Faridi, Pegah
    Prakash, Punit
    Twombley, Katherine
    Haemmerich, Dieter
    [J]. CANCERS, 2022, 14 (05)
  • [9] Lyso-thermosensitive liposomal doxorubicin for treatment of bladder cancer
    Mikhail, Andrew S.
    Negussie, Ayele H.
    Pritchard, William F.
    Haemmerich, Dieter
    Woods, David
    Bakhutashvili, Ivane
    Esparza-Trujillo, Juan
    Brancato, Sam J.
    Karanian, John
    Agarwal, Piyush K.
    Wood, Bradford J.
    [J]. INTERNATIONAL JOURNAL OF HYPERTHERMIA, 2017, 33 (07) : 733 - 740
  • [10] Characterizing the immune microenvironment and examining the effect of tumour-targeted MRgHIFU mediated hyperthermia in combination with thermosensitive liposomal doxorubicin in a mouse model of embryonal rhabdomyosarcoma
    Nomikos, Julia
    Wunker, Claire
    Waspe, Adam C.
    Babichev, Yael
    Piorkowska, Karolina
    Wong, Suzanne
    Foltz, Warren
    Gerstle, J. Ted
    Demicco, Elizabeth G.
    Gupta, Abha A.
    Guidos, Cynthia J.
    Drake, James M.
    Gladdy, Rebecca A.
    [J]. CANCER RESEARCH, 2024, 84 (17)