SECONDARY STRUCTURE OF URACIL-DNA GLYCOSYLASE INHIBITOR PROTEIN

被引：12
|
作者：
BALASUBRAMANIAN, S
BEGER, RD
BENNETT, SE
MOSBAUGH, DW
BOLTON, PH
机构：
[1] WESLEYAN UNIV,DEPT CHEM,MIDDLETOWN,CT 06450
[2] OREGON STATE UNIV,DEPT AGR CHEM,CORVALLIS,OR 97331
[3] OREGON STATE UNIV,DEPT BIOCHEM & BIOPHYS,CORVALLIS,OR 97331
[4] OREGON STATE UNIV,CTR ENVIRONM HLTH SCI,CORVALLIS,OR 97331
来源：
JOURNAL OF BIOLOGICAL CHEMISTRY | 1995年 / 270卷 / 01期
关键词：
D O I：
10.1074/jbc.270.1.296
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Bacillus subtilis bacteriophage PBS2 uracil-DNA glycosylase inhibitor (Ugi) is an acidic protein of 84 amino acids that inactivates uracil-DNA glycosylase from diverse organisms (Wang, Z., and Mosbaugh, D, W. (1989) J. Biol. Chem. 264, 1163-1171). The secondary structure of Ugi has been determined by solution state multidimensional nuclear magnetic resonance, The protein adopts a single well defined structure consisting of five anti parallel beta-strands and two alpha-helices. Six loop or turn regions were identified that contain approximately one half of the acidic amino acid residues and connect the beta-strands sequentially to one another, The secondary structure suggests which regions of Ugi may be involved in interactions with uracil-DNA glycosylase.
引用
收藏
页码：296 / 303
页数：8
相关论文
共 50 条
  • [1] TERTIARY STRUCTURE OF URACIL-DNA GLYCOSYLASE INHIBITOR PROTEIN
    BEGER, RD
    BALASUBRAMANIAN, S
    BENNETT, SE
    MOSBAUGH, DW
    BOLTON, PH
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (28) : 16840 - 16847
  • [2] URACIL-DNA GLYCOSYLASE INHIBITOR PROTEIN-STRUCTURE
    MOSBAUGH, DW
    BENNETT, S
    LUNDQUIST, A
    BALASUBRAMANIAN, S
    BEGER, RD
    BOLTON, PH
    [J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 1995, : 296 - 296
  • [3] NUCLEOTIDE MIMICRY IN THE CRYSTAL-STRUCTURE OF THE URACIL-DNA GLYCOSYLASE-URACIL GLYCOSYLASE INHIBITOR PROTEIN COMPLEX
    SAVVA, R
    PEARL, LH
    [J]. NATURE STRUCTURAL BIOLOGY, 1995, 2 (09): : 752 - 757
  • [4] Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase
    Putnam, CD
    Shroyer, MJN
    Lundquist, AJ
    Mol, CD
    Arvai, AS
    Mosbaugh, DW
    Tainer, JA
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1999, 287 (02) : 331 - 346
  • [5] CRYSTAL-STRUCTURE OF HUMAN URACIL-DNA GLYCOSYLASE IN COMPLEX WITH A PROTEIN INHIBITOR - PROTEIN MIMICRY OF DNA
    MOL, CD
    ARVAI, AS
    SANDERSON, RJ
    SLUPPHAUG, G
    KAVLI, B
    KROKAN, HE
    MOSBAUGH, DW
    TAINER, JA
    [J]. CELL, 1995, 82 (05) : 701 - 708
  • [6] URACIL-DNA GLYCOSYLASE INHIBITOR GENE OF BACTERIOPHAGE PBS2 ENCODES A BINDING-PROTEIN SPECIFIC FOR URACIL-DNA GLYCOSYLASE
    WANG, Z
    MOSBAUGH, DW
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1989, 264 (02) : 1163 - 1171
  • [7] Complexes of the uracil-DNA glycosylase inhibitor protein, Ugi, with Mycobacterium smegmatis and Mycobacterium tuberculosis uracil-DNA glycosylases
    Acharya, N
    Kumar, P
    Varshney, U
    [J]. MICROBIOLOGY-SGM, 2003, 149 : 1647 - 1658
  • [8] Staphylococcus aureus protein SAUGI acts as a uracil-DNA glycosylase inhibitor
    Wang, Hao-Ching
    Hsu, Kai-Cheng
    Yang, Jinn-Moon
    Wu, Mao-Lun
    Ko, Tzu-Ping
    Lin, Shen-Rong
    Wang, Andrew H. -J.
    [J]. NUCLEIC ACIDS RESEARCH, 2014, 42 (02) : 1354 - 1364
  • [9] A unique uracil-DNA binding protein of the uracil DNA glycosylase superfamily
    Sang, Pau Biak
    Srinath, Thiruneelakantan
    Patil, Aravind Goud
    Woo, Eui-Jeon
    Varshney, Umesh
    [J]. NUCLEIC ACIDS RESEARCH, 2015, 43 (17) : 8452 - 8463
  • [10] URACIL-DNA GLYCOSYLASE AS A PROBE FOR PROTEIN - DNA INTERACTIONS
    DEVCHAND, PR
    MCGHEE, JD
    VANDESANDE, JH
    [J]. NUCLEIC ACIDS RESEARCH, 1993, 21 (15) : 3437 - 3443
12345