MUPIROCIN RESISTANCE AMONG CONSECUTIVE ISOLATES OF OXACILLIN-RESISTANT AND BORDERLINE OXACILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS AT A UNIVERSITY HOSPITAL

被引：37
|
作者：
LAYTON, MC
PATTERSON, JE
机构：
[1] YALE UNIV,SCH MED,DEPT MED,INFECT DIS SECT,NEW HAVEN,CT 06520
[2] YALE UNIV,SCH MED,DEPT LAB MED,NEW HAVEN,CT 06520
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1994年 / 38卷 / 07期
关键词：
D O I：
10.1128/AAC.38.7.1664
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Mupirocin resistance was determined in consecutive oxacillin-resistant and borderline oxacillin-resistant Staphylococcus aureus clinical isolates collected over 14 months at a university hospital during 1991 and 1992. Twenty of 86 (23%) oxacillin-resistant and borderline oxacillin-resistant S. aureus isolates were mupirocin resistant; 80% were high-level resistant. Prior mupirocin use was a significant risk factor (relative risk, 6.08; 95% confidence interval, 3.7 to 9.99). Seven of 20 resistant isolates were distinct strains, as determined by pulsed-field gel electrophoresis typing. Two instances of clonal dissemination of a single strain occurred, but several other distinct mupirocin-resistant strains were documented. Mupirocin resistance was unexpectedly common among these isolates.
引用
收藏
页码：1664 / 1667
页数：4
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