METABOTROPIC GLUTAMATE RECEPTOR-INDUCED DISINHIBITION IS MEDIATED BY REDUCED TRANSMISSION AT EXCITATORY SYNAPSES ONTO INTERNEURONS AND INHIBITORY SYNAPSES ONTO PYRAMIDAL CELLS

被引：59
|
作者：
DESAI, MA
MCBAIN, CJ
KAUER, JA
CONN, PJ
机构：
[1] EMORY UNIV,SCH MED,DEPT PHARMACOL,ATLANTA,GA 30322
[2] DUKE UNIV,MED CTR,DEPT NEUROBIOL,DURHAM,NC 27710
来源：
NEUROSCIENCE LETTERS | 1994年 / 181卷 / 1-2期
关键词：
METABOTROPIC GLUTAMATE RECEPTOR; SYNAPTIC INHIBITION; ACPD; INHIBITORY POSTSYNAPTIC POTENTIAL; INTERNEURON; HIPPOCAMPUS;
D O I：
10.1016/0304-3940(94)90564-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Previous studies suggest that activation of metabotropic glutamate receptors (mGluRs) reduces GABA-mediated synaptic inhibition in area CA1 of the hippocampus. However, the mechanisms involved in this disinhibition are not known. We report that mGluR activation reduces both the GABA(A) and GABA(B) receptor-mediated components of evoked inhibitory postsynaptic potentials (IPSPs) by reducing transmission at excitatory synapses onto inhibitory interneurons and inhibitory synapses onto CA1 pyramidal cells.
引用
收藏
页码：78 / 82
页数：5
相关论文
共 20 条
  • [1] Astrocytes detect and upregulate transmission at inhibitory synapses of somatostatin interneurons onto pyramidal cells
    Marco Matos
    Anthony Bosson
    Ilse Riebe
    Clare Reynell
    Joanne Vallée
    Isabel Laplante
    Aude Panatier
    Richard Robitaille
    Jean-Claude Lacaille
    Nature Communications, 9
  • [2] Astrocytes detect and upregulate transmission at inhibitory synapses of somatostatin interneurons onto pyramidal cells
    Matos, Marco
    Bosson, Anthony
    Riebe, Ilse
    Reynell, Clare
    Vallee, Joanne
    Laplante, Isabel
    Panatier, Aude
    Robitaille, Richard
    lacaille, Jean-ClauDe
    NATURE COMMUNICATIONS, 2018, 9
  • [3] Excitatory synapses from CA3 pyramidal cells onto neighboring pyramidal cells differ from those onto inhibitory interneurons
    Aaron, GB
    Dichter, MA
    SYNAPSE, 2001, 42 (04) : 199 - 202
  • [4] Distinct in vivo dynamics of excitatory synapses onto cortical pyramidal neurons and parvalbumin-positive interneurons
    Melander, Joshua B.
    Nayebi, Aran
    Jongbloets, Bart C.
    Fortin, Dale A.
    Qin, Maozhen
    Ganguli, Surya
    Mao, Tianyi
    Zhong, Haining
    CELL REPORTS, 2021, 37 (06):
  • [5] Coordinated increase in inhibitory and excitatory synapses onto retinal ganglion cells during development
    Soto, Florentina
    Bleckert, Adam
    Lewis, Renate
    Kang, Yunhee
    Kerschensteiner, Daniel
    Craig, Ann Marie
    Wong, Rachel O. L.
    NEURAL DEVELOPMENT, 2011, 6
  • [6] Coordinated increase in inhibitory and excitatory synapses onto retinal ganglion cells during development
    Florentina Soto
    Adam Bleckert
    Renate Lewis
    Yunhee Kang
    Daniel Kerschensteiner
    Ann Marie Craig
    Rachel OL Wong
    Neural Development, 6
  • [7] Contextual Learning Requires Functional Diversity at Excitatory and Inhibitory Synapses onto CA1 Pyramidal Neurons
    Mitsushima, Dai
    AIMS NEUROSCIENCE, 2015, 2 (01) : 7 - 17
  • [8] Linking synaptic plasticity and spike output at excitatory and inhibitory Synapses onto cerebellar Purkinje cells
    Mittmann, Wolfgang
    Hausser, Michael
    JOURNAL OF NEUROSCIENCE, 2007, 27 (21): : 5559 - 5570
  • [9] CHOLINERGIC POTENTIATION OF GABAERGIC TONUS ONTO HIPPOCAMPAL PYRAMIDAL CELLS - A POSSIBLE DIRECT EXCITATORY ACTION ON INHIBITORY INTERNEURONS
    BEHRENDS, JC
    TENBRUGGENCATE, G
    EUROPEAN JOURNAL OF NEUROSCIENCE, 1992, : 58 - 58
  • [10] Endocannabinoid-Mediated Long-Term Depression of Afferent Excitatory Synapses in Hippocampal Pyramidal Cells and GABAergic Interneurons
    Peterfi, Zoltan
    Urban, Gabriella M.
    Papp, Orsolya I.
    Nemeth, Beata
    Monyer, Hannah
    Szabo, Gabor
    Erdelyi, Ferenc
    Mackie, Ken
    Freund, Tamas F.
    Hajos, Norbert
    Katona, Istvan
    JOURNAL OF NEUROSCIENCE, 2012, 32 (41): : 14448 - 14463
12