Current Approaches for New TB Drugs

被引：1

作者：

Pandey, Shilpika ^{[1
]}

Soni, Isha ^{[1
]}

Topno, Neha ^{[1
]}

Dasgupta, Arunava ^{[1
]}

Chopra, Sidharth ^{[1
]}

机构：

[1] CSIR Cent Drug Res Inst, Div Microbiol, BS 10-1,Sect 10,Janakipuram Extension,Sitapur Rd, Lucknow 226031, Uttar Pradesh, India

来源：

CURRENT RESPIRATORY MEDICINE REVIEWS | 2014年 / 10卷 / 02期

关键词：

Clinical strains; drugs; MIC; Mycobacterium; pre-clinical development; tuberculosis;

D O I：

10.2174/1573398X10666140813201210

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Tuberculosis is essentially a curable disease but inspite of a WHO approved DOTS therapy, it still continues to ravage mankind. This situation is exacerbated by long course of chemotherapy, increasing drug resistance and co-emergence with HIV. The TB drug pipeline remained stagnant for a long time with no new drug approved till FDA approval for Bedaquiline. This situation has now improved with a number of agents in pre-clinical and clinical development against M. tuberculosis. In this review, we are focusing on some of the newer drugs in discovery and preclinical development against M. tuberculosis.

引用

页码：88 / 96

页数：9

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