Human Interferon Alpha-2b: A Therapeutic Protein for Cancer Treatment

被引：67
|
作者：
Ningrum, Ratih Asmana [1 ]
机构：
[1] Cibinong Sci Ctr, Biotechnol Res Ctr, Jalan Raya Bogor Km 46, Bogor 16911, West Java, Indonesia
来源：
SCIENTIFICA | 2014年 / 2014卷
关键词：
D O I：
10.1155/2014/970315
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Human interferon alpha (hIFN alpha) is a wide biological activity cytokine that is used in hepatitis and cancer treatments. It regulates many genes that are involved in antiviral and antiproliferative activities. This mini review focuses on human interferon alpha-2b (hIFN alpha-2b) as therapeutic protein for cancer treatment. The review covers hIFN alpha-2b molecular characteristic and its molecular mechanism by Janus activated kinase/signal transducer activation of transcription (JAK-STAT) pathway. The JAK-STAT pathway regulates not only proteins involved in inhibition of proliferation but also apoptosis. As additional discussion of clinical applications, the use of recombinant hIFN alpha-2b (rhIFN alpha-2b) as therapeutic protein in several types of cancer is also explained.
引用
收藏
页数：8
相关论文
共 50 条
  • [1] THERAPEUTIC USE OF INTERFERON ALPHA-2B - INTRODUCTION
    MARMONT, A
    [J]. EUROPEAN JOURNAL OF HAEMATOLOGY, 1990, 45 : 1 - 2
  • [2] INTERFERON ALPHA-2B IN THE TREATMENT OF MYELOFIBROSIS
    FURESI, L
    PASINI, FL
    FORCONI, S
    [J]. HAEMATOLOGICA, 1990, 75 (06) : 587 - 589
  • [3] THERAPEUTIC TRIAL OF INTRALESIONAL ALPHA-2B INTERFERON IN KELOIDS
    ESPINASSOUZE, F
    HEID, E
    GROSSHANS, E
    [J]. ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE, 1993, 120 (09): : 629 - 630
  • [4] Trichomegaly following treatment with interferon alpha-2b
    Hernández-Núnéz, A
    Fernández-Herrera, J
    Buceta, LR
    García-Díez, A
    [J]. LANCET, 2002, 359 (9312): : 1107 - 1107
  • [5] TREATMENT OF ESSENTIAL THROMBOCYTHEMIA WITH INTERFERON ALPHA-2B
    MAY, D
    WANDL, UB
    NIEDERLE, N
    [J]. LANCET, 1989, 1 (8629): : 96 - 96
  • [6] Ineffective treatment of keloids with interferon alpha-2b
    Davison, SP
    Mess, S
    Kauffman, LC
    Al-Attar, A
    [J]. PLASTIC AND RECONSTRUCTIVE SURGERY, 2006, 117 (01) : 247 - 252
  • [7] Treatment of eosinophilic gastroenteritis with interferon alpha-2b
    Crockett, RE
    Ledford, DK
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2002, 109 (01) : S206 - S206
  • [8] TREATMENT WITH NATURAL HUMAN INTERFERON ALPHA OF A CML-PATIENT WITH ANTIBODIES TO RECOMBINANT INTERFERON ALPHA-2B
    FREUND, M
    VONWUSSOW, P
    KNUVERHOPF, J
    MOHR, H
    POHL, U
    EXERIEDE, G
    LINK, H
    WILKE, HJ
    POLIWODA, H
    [J]. BLUT, 1988, 57 (05): : 311 - 315
  • [9] Structure, biology, and therapeutic implications of pegylated interferon alpha-2b
    Youngster, S
    Wang, YS
    Grace, M
    Bausch, J
    Bordens, R
    Wyss, DF
    [J]. CURRENT PHARMACEUTICAL DESIGN, 2002, 8 (24) : 2139 - 2157
  • [10] ALPHA-2B INTERFERON AND HYPOTHYROIDISM
    JAVIER, RM
    SIBILIA, J
    KUNTZ, JL
    SCHLIENGER, JL
    ASCH, L
    [J]. REVUE DU RHUMATISME, 1992, 59 (7-8): : 501 - 501
12345