Brachytherapy for patients with uveal melanoma: historical perspectives and future treatment directions

被引：22
|
作者：
Brewington, Beatrice Y. [1 ]
Shao, Yusra F. [2 ]
Davidorf, Fredrick H. [1 ]
Cebulla, Colleen M. [1 ]
机构：
[1] Ohio State Univ, Havener Eye Inst, Dept Ophthalmol & Visual Sci, Columbus, OH 43210 USA
[2] Ohio State Univ, Coll Med, Med Student Res Program, Columbus, OH 43210 USA
来源：
CLINICAL OPHTHALMOLOGY | 2018年 / 12卷
关键词：
brachytherapy; uveal melanoma; UM; fine-needle-aspiration biopsy; genetic prognostic testing; molecular markers;
D O I：
10.2147/OPTH.S129645
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Surgical management with enucleation was the primary treatment for uveal melanoma (UM) for over 100 years. The Collaborative Ocular Melanoma Study confirmed in 2001 that globe-preserving episcleral brachytherapy for UM was safe and effective, demonstrating no survival difference with enucleation. Today, brachytherapy is the most common form of radiotherapy for UM. We review the history of brachytherapy in the treatment of UM and the evolution of the procedure to incorporate fine-needle-aspiration biopsy techniques with DNA-and RNA-based genetic prognostic testing.
引用
收藏
页码：925 / 934
页数：10
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