Formulation, characterization, and evaluation of matrix-type transdermal patches of a model antihypertensive drug

被引：11
|
作者：
Jamakandi, V. G. [1 ]
Mulla, J. S. [1 ]
Vinay, B. L. [1 ]
Shivakumar, H. N. [2 ]
机构：
[1] KLES Coll Pharm, Dept Pharmaceut, Hubli 580031, India
[2] KLES Coll Pharm, Dept Pharmaceut, Bangalore, Karnataka, India
来源：
ASIAN JOURNAL OF PHARMACEUTICS | 2009年 / 3卷 / 01期
关键词：
HPMC; in vitro release study; nicorandil; porcine ear skin and permeation study; transdermal patch;
D O I：
10.4103/0973-8398.49177
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The present investigation was aimed to evaluating the possibility of using different polymeric grades of hydroxy propyl methyl cellulose (6cps, 15cps, and K4M) for the development of transdermal drug delivery systems of nicorandil, an antianginal drug. Prepared matrix-type patches were evaluated for their physicochemical characterization followed by in vitro evaluation. Selected formulations were subjected for their ex vivo studies on porcine ear skin.
引用
收藏
页码：59 / 65
页数：7
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