Infliximab in the Treatment of Refractory Ocular Inflammatory Diseases

Purpose: Infliximab is frequently used in the treatment of refractory rheumatic diseases. We report our initial local experience at a tertiary eye center in Hong Kong in using infliximab as treatment of various refractory ocular inflammatory diseases that have failed with conventional corticosteroid and immunosuppressant therapy. Design: This is a retrospective, interventional case series. Methods: We reviewed all the medical records of patients who had refractory ocular inflammatory diseases and received infliximab as part of their treatment. We collected data regarding the visual acuity, status of inflammation, and any complications arising from the treatment. Results: Seven eyes from 3 male and 2 female patients were recruited. Two patients had peripheral ulcerative keratitis, whereas the remaining patients had uveitis. Two patients had bilateral diseases, and the rest were unilateral. All patients achieved quiescence after 3 doses of infliximab infusions during the period of 3 months. Most of the patients retained a useful visual acuity of 20/70 or better at the end of the study. There were no serious adverse effects or complications encountered from the infliximab therapy. Conclusions: Infliximab is a valuable and potent option that may be considered in the management of various refractory ocular inflammatory diseases. However, larger controlled studies are needed to evaluate the safety profile, optimal treatment schedule, and adverse effects of long-term infliximab therapy.