Intratympanic injection of hydrogel nanodrug for the prevention and treatment of sensorineural hearing loss

被引：0

作者：

Tianying Zhai ^{[1
,2
,3
,4
]}

Pingping Ai ^{[1
,2
,3
,4
,5
]}

Zhaohui Tang ^{[6
]}

Chaoliang He ^{[6
]}

Xuesi Chen ^{[6
]}

Shiming Yang ^{[1
,2
,3
,4
]}

Nan Wu ^{[1
,2
,3
,4
]}

机构：

[1] Senior Department of Otolaryngology-Head & Neck Surgery, PLA General Hospital

[2] National Clinical Research Center for Otolaryngologic Disease

[3] State Key Lab of Hearing Science, Ministry of Education

[4] Beijing Key Lab of Hearing Impairment Prevention & Treatment

[5] Zhejiang Chinese Medical University

[6] Changchun Institute of Applied Chemistry, Chinese Academy of Sciences

来源：

Journal of Otology | 2023年 / 18卷 / 04期

关键词：

D O I：

暂无

中图分类号：

R764.43 [耳聋];

学科分类号：

100213 ;

摘要：

Safe and efficient drug delivery to the inner ear has always been the focus of prevention and treatment of sensorineural deafness. The rapid development of nanodrug delivery systems based on hydrogel has provided a new opportunity. Among them, thermo-sensitive hydrogels promote the development of new dosage form for intratympanic injection. This smart biomaterial could transform to semisolid phase when the temperature increased. Thermo-sensitive hydrogel nanodrug delivery system is expected to achieve safe, efficient, and sustained inner ear drug administration. This article introduces the key techniques and the latest progress in this field.

引用

页码：235 / 239

页数：5

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