CYP2D6、CYP2C19、CYP2B6、SLC6A4、HTR2A基因型和5-羟色胺再摄取抑制剂抗抑郁药:2023年CPIC指南解读

被引：0

作者：

周长凯

于红霞

曹铭晨

史云燕

刘东华

纪洪艳

邢晓敏

王心怡

李静

荆凡波

机构：

[1] 青岛大学附属医院药学部

来源：

药学研究 | 2024年 / 43卷 / 05期

关键词：

指南; 基因多态性; 5-羟色胺再摄取抑制剂; 抗抑郁药; 解读;

D O I：

10.13506/j.cnki.jpr.2024.05.014

中图分类号：

R971.4 [];

学科分类号：

摘要：

2023年临床药物基因组学实施联盟(CPIC)更新并扩展了2015年CYP2D6和CYP2C19基因型与选择性5-羟色胺再摄取抑制剂(SSRIs)治疗指南，在涉及基因型与药物部分分别增加了CYP2B6、5-羟色胺转运体SLC6A4、5-羟色胺2A受体HTR2A以及5-羟色胺与去甲肾上腺素再摄取抑制剂(SNRIs)、类SSRIs活性的5-羟色胺(5-HT)调节剂相关内容，并更新了基于基因多态性的5-HT再摄取抑制剂类药物应用建议。本文对该指南相关内容进行解读，以期为我国5-HT再摄取抑制剂类药物个体化药物管理提供参考。

引用

页码：495 / 503

页数：9

共 21 条

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