Mechanisms of PARP inhibitor resistance in cancer and insights into the DNA damage response

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作者：
Paola Francica
Sven Rottenberg
机构：
[1] University of Bern,Institute of Animal Pathology, Vetsuisse Faculty, Länggassstrasse
[2] The Netherlands Cancer Institute,Division of Molecular Pathology
来源：
Genome Medicine | / 10卷
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摘要：
Inhibitors of poly(ADP-ribose) polymerase (PARPi) have entered the clinic for the treatment of patients with cancers that lack homology-directed DNA repair, but drug resistance remains a clinical hurdle. Recent advances in the identification of PARPi resistance mechanisms have yielded a better understanding of DNA end protection and the relevance of endogenous poly(ADP-ribose) glycohydrolase, highlighting new vulnerabilities.
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