Reaction of Neurons to Alkaloid Agonists of Opioid Receptors during Modulation of Phosphodiesterases

被引：0
|
作者：
O. I. Epstein
M. B. Shtark
T. A. Zapara
O. G. Simonova
A. S. Ratushnyak
机构：
[1] “Materia Medica Holding” Research-and-Production Company,Siberian Division of the Russian Academy of Medical Sciences
[2] Institute of Molecular Biology and Biophysics,Siberian Division of the Russian Academy of Sciences
[3] Construction-and-Technological Institute of Computational Technologies,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2003年 / 135卷 / Suppl 7期
关键词：
ultralow doses; signal systems; ion permeability of membrane; theophylline; morphine;
D O I：
10.1023/A:1024745705881
中图分类号：
学科分类号：
摘要：
We studied the effect of ultralow doses of theophylline and morphine, modulators of receptors and intracellular signal systems, on ion permeability of membranes. Theophylline and morphine in ultralow doses blocked the neuronal responses to these agents applied in physiological concentrations. Theophylline in ultralow doses attenuated, but did not completely block neuronal reaction to morphine. These findings suggest that ultralow doses of various substances producing no appreciable physiological changes can activate mechanisms providing optimum response to strong factors.
引用
收藏
页码：17 / 19
页数：2
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