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- [2] Going mad with SmadsNEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (15): : 1144 - 1146Zhou, SBKinzler, KWVogelstein, B
Mad about SMADs
被引：0
|作者：
Jeff Wrans
Tony Pawson
机构：
[1] The Hospital for Sick Children,Program in Developmental Biology and Division of Gastroenterology
[2] Program in Molecular Biology and Cancer,undefined
[3] Samuel Lunenfeld Research Institute,undefined
[4] Mount Sinai Hospital,undefined
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摘要：
Signalling through the transforming growth factor-beta (TGF-beta) requires the so-called Smad proteins, and two papers now show how the Smads work. TGF-beta binds to its receptor, which then activates Smad2 to form a transcriptionally active complex with Smad4. But the crystal structure of Smad4 shows that its carboxy-terminal domain can join up with its amino-terminal domain, to prevent the formation of a complex and, hence, to inhibit TGF-beta- mediated signalling.
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页码：28 / 29
页数：1
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